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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
6.36
Human Site:
S46
Identified Species:
11.67
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
S46
D
F
L
R
N
L
F
S
Q
T
L
S
L
G
S
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
R33
P
L
D
E
K
H
C
R
R
V
I
C
L
V
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
T46
D
F
L
R
N
L
F
T
Q
T
L
G
L
G
S
Rat
Rattus norvegicus
Q5RJQ4
350
39301
S36
G
V
T
R
Y
M
Q
S
E
R
C
R
R
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
R60
L
L
R
N
L
L
A
R
T
L
G
L
G
T
E
Frog
Xenopus laevis
NP_001088636
413
45548
F74
M
D
F
L
R
N
L
F
S
R
T
L
G
I
G
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
F44
M
D
F
L
R
S
L
F
S
R
T
L
G
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
H41
S
F
D
G
F
A
E
H
W
R
V
H
G
F
R
Honey Bee
Apis mellifera
XP_393038
355
40940
K41
I
R
K
Y
L
A
Q
K
L
R
L
F
D
S
S
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
Q79
M
S
N
L
R
R
A
Q
R
L
L
D
D
G
A
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
S43
R
F
H
L
S
A
G
S
S
G
Q
E
E
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
P42
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
0
N.A.
6.6
N.A.
86.6
13.3
N.A.
N.A.
6.6
0
6.6
N.A.
6.6
13.3
13.3
13.3
P-Site Similarity:
100
0
N.A.
20
N.A.
93.3
26.6
N.A.
N.A.
6.6
0
6.6
N.A.
13.3
13.3
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
24
16
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
8
0
8
0
0
0
8
8
0
0
0
% C
% Asp:
16
16
16
0
0
0
0
0
8
0
0
8
16
0
0
% D
% Glu:
0
0
0
8
0
0
8
0
8
0
0
8
8
0
8
% E
% Phe:
0
31
16
0
8
0
16
16
0
8
0
8
0
8
0
% F
% Gly:
8
0
0
8
0
8
8
0
0
8
8
8
31
31
16
% G
% His:
0
0
8
0
0
8
0
8
0
0
0
8
0
0
0
% H
% Ile:
16
0
0
0
0
0
8
0
0
0
8
0
0
8
8
% I
% Lys:
0
0
8
0
8
0
0
8
0
0
0
0
0
8
0
% K
% Leu:
8
16
16
31
16
24
16
0
8
16
31
24
24
8
0
% L
% Met:
24
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
16
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
8
0
0
0
0
8
0
8
% P
% Gln:
0
0
0
0
0
0
16
8
16
0
8
0
0
0
0
% Q
% Arg:
8
8
8
24
24
8
0
16
16
39
8
8
8
0
8
% R
% Ser:
8
16
0
8
8
8
0
24
24
0
0
16
0
8
31
% S
% Thr:
0
0
16
0
0
0
0
8
8
16
16
0
0
8
8
% T
% Val:
0
8
0
0
0
0
0
0
0
8
8
0
0
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _